SF 4000 SFC

The use of supercritical fluid chromatography is a green alternative to traditional HPLC, with the use of CO2 taking the place of organic solvent as the mobile phase. CO2 has benefits for cost, health, and safety , as well as faster, cleaner sample recovery during sample purification. Other advantages of supercritical fluid chromatography include low viscosity with liquid-like densities, for higher solubility and increased column loading. The low viscosity and high diffusion lead to faster separations and faster extractions.

SFC has long been the method of choice for chiral separations, but with a large (and rapidly growing) range of column phases available – SFC is now becoming a powerful tool for achiral separations, both analytically and for sample prep.

BENEFITS

High Solubility & Low Viscosity

Greater solubility and lower viscosity than liquid phase HPLC leading to rapid column equilibration, faster separations and higher productivity.

Wide Molecular Structure Coverage

Applicable to a wide range of molecular structures with a wide range of polarities from strongly hydrophobic to strongly hydrophilic.

Environment-Friendly

SFC uses simple separation solvents – generally CO2 with alcoholic modifiers – which are much greener than other solvents generally used in NPLC and RPLC.

Cost-Effective

Dramatic reduction in solvent costs for both purchase and disposal.

Straightforward Operation

SFC scales-up from analytical to preparative with ease, so method development for high quality chiral and achiral sample purification with low solvent contamination is completely straightforward.